Karthus Support is ranked Off Meta Tier and has a 33.84% win rate in LoL Patch 9.24. We've analyzed 565 Karthus Support games to compile our statistical Karthus Build Guide. For items, our build recommends: Sorcerer's Shoes, Luden's Echo, Morellonomicon, Zhonya's Hourglass, Rabadon's Deathcap, and Shard of True Ice. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Flash and Ignite. Starting items should include Health Potion, Spellthief's Edge, Doran's Ring, Refillable Potion, and Warding Totem (Trinket). Karthus's Best Support matchups include Zilean, Braum, and Gragas. Karthus's Best Support counters are Zyra, Yuumi, and Nautilus.
Karthus Summoner Spells






Karthus Starting Items





Karthus Runes
Karthus Items








Karthus Skill Order
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Karthus Trinkets



Karthus Boots





