Karthus Mid Lane is ranked A Tier and has a 61.02% win rate in LoL Patch 8.24. We've analyzed 1066 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Rod of Ages, Sorcerer's Shoes, Morellonomicon, Zhonya's Hourglass, Liandry's Torment, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Flash and Teleport. Starting items should include Health Potion, Doran's Ring, Refillable Potion, The Dark Seal, and Warding Totem (Trinket). Karthus's Best Mid Lane matchups include Akali, Karma, and Lissandra. Karthus's Best Mid Lane counters are Blitzcrank, Heimerdinger, and Xerath.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
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 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Trinkets
Karthus Boots
Average Jungle Duo Queue Champions for Karthus Mid Lane(49% - 51% win rate with Karthus)
Even Mid Lane Matchups for Karthus Mid Lane(49% - 51% win rate for Karthus)
