Tier: BWin50.99%Role18.68%Pick0.28%Ban0.74%Games: 52KDA: 1.89Score: 47.92
Karthus Mid Lane is ranked B Tier and has a 50.99% win rate in LoL Patch 10.25. We've analyzed 52 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Sorcerer's Shoes, Liandry's Anguish, Demonic Embrace, Zhonya's Hourglass, Void Staff, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Flash and Barrier. Starting items should include Doran's Ring, Health Potion, and Stealth Ward. Karthus's Best Mid Lane matchups include Yasuo, Yone, and Zed.
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Karthus Summoner Spells


Win %
Pick %
56%
100%
68%
48%

39%
35%

50%
12%

100%
2%

50%
4%
Karthus Starting Items
Win %
Buy %


2

62%
75%



100%
2%
Karthus Runes
Win %
Pick %
60%
65%
53%
11%
100%
2%
0%
2%
Karthus Items

60%

57%

53%

60%

56%

75%

57%

70%
Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | Q | Q | Q | Q | Q | |||||||||||||
![]() | W | W | W | W | W | |||||||||||||
![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Item Purchase Order


























Karthus Trinkets
Win %
Buy %

57%
90%

57%
13%

43%
13%
Karthus Boots
Win %
Buy %

60%
90%

33%
6%
Karthus Mythic Items
Win %
Buy %

57%
77%

75%
8%

50%
12%

0%
2%