Tier: Off MetaWin20.00%Role3.11%Pick0.07%Ban0.74%Games: 11KDA: 1.52Score: 41.57
Karthus Mid Lane is ranked Off Meta Tier and has a 20.00% win rate in LoL Patch 25.09. We've analyzed 11 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Malignance, Sorcerer's Shoes, Liandry's Torment, Mejai's Soulstealer, Seraph's Embrace, and Rabadon's Deathcap. For runes, the strongest choice is Inspiration (Primary) with First Strike (Keystone), and Sorcery (Secondary). The optimal Summoner Spells for this build are Exhaust and Ignite. Starting items should include Doran's Ring, Health Potion, and Stealth Ward. Karthus's Best Mid Lane matchups include Yasuo.
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Karthus Summoner Spells


Win %
Pick %
50%
73%
40%
45%

25%
36%

20%
45%
Karthus Starting Items
Win %
Buy %


2

17%
55%
Karthus Runes
Win %
Pick %
100%
18%
26%
71%
0%
9%
Karthus Items

25%

38%

33%

50%

75%

100%

40%

100%
Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | Q | Q | Q | Q | Q | |||||||||||||
![]() | W | W | W | W | W | |||||||||||||
![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Item Purchase Order






















Karthus Trinkets
Win %
Buy %

40%
91%

25%
36%
Karthus Boots
Win %
Buy %

38%
73%
Karthus Situational Items
Win %
Buy %

60%
45%

50%
18%

20%
45%

0%
9%

0%
9%