Karthus Mid Lane is ranked B Tier and has a 42.82% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 154 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Sorcerer's Shoes, Liandry's Anguish, Archangel's Staff, Shadowflame, Rabadon's Deathcap, and Void Staff. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Doran's Ring, Health Potion, and Stealth Ward. Karthus's Best Spellbook Mid Lane matchups include Akali, Corki, and Vladimir. Karthus's Best Spellbook Mid Lane counters are LeBlanc, Viktor, and Zed.
Karthus Summoner Spells






Karthus Starting Items








Karthus Runes
Karthus Items








Karthus Skill Order
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Karthus Item Purchase Order























Karthus Ultimate Spellbook Stats



























































Karthus Trinkets



Karthus Boots


Karthus Mythic Items




