Tier: Off MetaWin40.83%Role24.19%Pick0.53%Games: 24KDA: 2.21Score: 45.36
Karthus Mid Lane is ranked Off Meta Tier and has a 40.83% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 24 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Liandry's Anguish, Sorcerer's Shoes, Void Staff, Rabadon's Deathcap, Mejai's Soulstealer, and Seraph's Embrace. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Doran's Ring, Dark Seal, and Health Potion. Karthus's Best Spellbook Mid Lane matchups include Vladimir.
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Karthus Summoner Spells


Win %
Pick %
63%
100%
58%
79%

75%
17%

100%
4%
Karthus Starting Items
Win %
Buy %



4
67%
13%



2

100%
4%
Karthus Runes
Win %
Pick %
71%
39%
72%
25%
86%
5%
100%
4%
Karthus Items

72%

65%

55%

65%

100%

78%

67%

55%
Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
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![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Item Purchase Order




















Karthus Ultimate Spellbook Stats

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Karthus Trinkets
Win %
Buy %

67%
88%

60%
42%

67%
13%
Karthus Boots
Win %
Buy %

65%
96%

100%
4%
Karthus Mythic Items
Win %
Buy %

72%
75%

33%
25%

50%
8%

100%
4%