Karthus Mid Lane is ranked S Tier and has a 52.80% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 68 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Liandry's Anguish, Sorcerer's Shoes, Archangel's Staff, Zhonya's Hourglass, Rabadon's Deathcap, and Void Staff. For runes, the strongest choice is Inspiration (Primary) with First Strike (Keystone), and Domination (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Tear of the Goddess, Health Potion, and Stealth Ward. Karthus's Best Spellbook Mid Lane matchups include Yasuo. Karthus's Best Spellbook Mid Lane counters are Lissandra and Yone.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
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 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Item Purchase Order
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2800Karthus Ultimate Spellbook Stats
Karthus Trinkets
Karthus Boots
Karthus Mythic Items
Average Jungle Duo Queue Champions for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate with Karthus)
Best Mid Lane Matchups for Karthus Mid Lane in Ultimate Spellbook(over 51% win rate for Karthus)
Even Mid Lane Matchups for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate for Karthus)
