Karthus Support is ranked Off Meta Tier and has a 56.46% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 92 Karthus Support games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Liandry's Anguish, Sorcerer's Shoes, Zhonya's Hourglass, Rabadon's Deathcap, Demonic Embrace, and Shard of True Ice. For runes, the strongest choice is Inspiration (Primary) with First Strike (Keystone), and Domination (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Spellthief's Edge, Health Potion, and Stealth Ward. Karthus's Best Spellbook Support matchups include Nautilus. Karthus's Best Spellbook Support counters are Seraphine, Vel'Koz, and Morgana.
Karthus Summoner Spells





Karthus Starting Items








Karthus Runes
Karthus Items








Karthus Skill Order
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Karthus Item Purchase Order


















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Karthus Trinkets



Karthus Boots



Karthus Mythic Items



