Karthus Mid Lane is ranked A Tier and has a 56.56% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 388 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Liandry's Anguish, Sorcerer's Shoes, Archangel's Staff, Demonic Embrace, Rabadon's Deathcap, and Void Staff. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Sorcery (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Tear of the Goddess, Health Potion, and Stealth Ward. Karthus's Best Spellbook Mid Lane matchups include Yasuo, Sylas, and Anivia. Karthus's Best Spellbook Mid Lane counters are Kassadin, Akshan, and Cho'Gath.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
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 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Item Purchase Order
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36002800Karthus Ultimate Spellbook Stats
Karthus Trinkets
Karthus Boots
Karthus Mythic Items
Average Jungle Duo Queue Champions for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate with Karthus)
Even Mid Lane Matchups for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate for Karthus)
