Vayne ADC is ranked S Tier and has a 53.55% win rate in LoL Patch 13.24. We've analyzed 109252 Vayne ADC games to compile our statistical Vayne Build Guide. For items, our build recommends: Berserker's Greaves, Statikk Shiv, Kraken Slayer, Trinity Force, Blade of The Ruined King, and Wit's End. For runes, the strongest choice is Precision (Primary) with Lethal Tempo (Keystone), and Resolve (Secondary). The optimal Summoner Spells for this build are Flash and Ghost. Starting items should include Doran's Blade, Health Potion, and Stealth Ward. Vayne's Best ADC matchups include Zeri, Ziggs, and Tristana. Vayne's Best ADC counters are Tahm Kench, Veigar, and Seraphine.