Karthus Mid Lane is ranked A Tier and has a 63.04% win rate in LoL Patch 7.24. We've analyzed 46 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Rod of Ages, Morellonomicon, Sorcerer's Shoes, Archangel's Staff, Liandry's Torment, and Rabadon's Deathcap. For runes, the strongest choice is Sorcery (Primary) with Summon Aery (Keystone), and <pathBonus><pathSorcery>Sorcery</pathSorcery> + <pathPrecision>Precision</pathPrecision> </pathBonus> (Secondary). The optimal Summoner Spells for this build are Flash and Teleport. Starting items should include Health Potion, Doran's Ring, Faerie Charm, Sapphire Crystal, and Warding Totem (Trinket). Karthus's Best Mid Lane matchups include Ryze, Twisted Fate, and Xerath.
Karthus Summoner Spells



Karthus Starting Items





Karthus Runes
Karthus Items








Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | Q | Q | Q | Q | Q | |||||||||||||
![]() | W | W | W | W | W | |||||||||||||
![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Trinkets



Karthus Boots
