Vayne Mid Lane is ranked Off Meta Tier and has a 46.51% win rate in LoL Patch 7.24. We've analyzed 43 Vayne Mid Lane games to compile our statistical Vayne Build Guide. For items, our build recommends: Berserker's Greaves, Blade of the Ruined King, Statikk Shiv, Infinity Edge, Phantom Dancer, and Rapid Firecannon. For runes, the strongest choice is Precision (Primary) with Press the Attack (Keystone), and <pathBonus><pathPrecision>Precision</pathPrecision> + <pathDomination>Domination</pathDomination> </pathBonus> (Secondary). The optimal Summoner Spells for this build are Flash and Heal. Starting items should include Health Potion, Doran's Blade, Doran's Shield, Corrupting Potion, and Warding Totem (Trinket). Vayne's Best Mid Lane matchups include Kassadin and Katarina. Vayne's Best Mid Lane counters are Zed.
Vayne Summoner Spells
Vayne Starting Items
Vayne Runes
Vayne Items
Vayne Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Vayne Trinkets
Vayne Boots
Best Jungle Duo Queue Champions for Vayne Mid Lane(over 51% win rate with Vayne)
Average Jungle Duo Queue Champions for Vayne Mid Lane(49% - 51% win rate with Vayne)
Best Mid Lane Champions to Counter Vayne Mid Lane(under 49% win rate for Vayne)
Even Mid Lane Matchups for Vayne Mid Lane(49% - 51% win rate for Vayne)
