Karthus Mid Lane is ranked C Tier and has a 46.53% win rate in LoL Patch 7.24. We've analyzed 144 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Sorcerer's Shoes, Rod of Ages, Rylai's Crystal Scepter, Zhonya's Hourglass, Liandry's Torment, and Rabadon's Deathcap. For runes, the strongest choice is Sorcery (Primary) with Arcane Comet (Keystone), and <pathBonus><pathSorcery>Sorcery</pathSorcery> + <pathPrecision>Precision</pathPrecision> </pathBonus> (Secondary). The optimal Summoner Spells for this build are Flash and Ignite. Starting items should include Health Potion, Doran's Ring, Refillable Potion, The Dark Seal, and Warding Totem (Trinket). Karthus's Best Mid Lane matchups include Annie and Veigar. Karthus's Best Mid Lane counters are Vel'Koz, Brand, and Syndra.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
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 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Trinkets
Karthus Boots
Average Jungle Duo Queue Champions for Karthus Mid Lane(49% - 51% win rate with Karthus)
Even Mid Lane Matchups for Karthus Mid Lane(49% - 51% win rate for Karthus)
