Vayne Mid Lane is ranked Off Meta Tier and has a 65.10% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 269 Vayne Mid Lane games to compile our statistical Vayne Spellbook Build Guide. For items, our build recommends: Berserker's Greaves, Immortal Shieldbow, Wit's End, Phantom Dancer, Blade of The Ruined King, and Bloodthirster. For runes, the strongest choice is Precision (Primary) with Lethal Tempo (Keystone), and Domination (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Boots, Dagger, Health Potion, and Stealth Ward. Vayne's Best Spellbook Mid Lane matchups include Ekko, Galio, and Lucian. Vayne's Best Spellbook Mid Lane counters are Ahri, Heimerdinger, and Neeko.
Vayne Summoner Spells
Vayne Starting Items
Vayne Runes
Vayne Items
Vayne Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Vayne Item Purchase Order
1100
3400
3100
2600
32003400Vayne Ultimate Spellbook Stats
Vayne Trinkets
Vayne Boots
Vayne Mythic Items
Average Jungle Duo Queue Champions for Vayne Mid Lane in Ultimate Spellbook(49% - 51% win rate with Vayne)
Even Mid Lane Matchups for Vayne Mid Lane in Ultimate Spellbook(49% - 51% win rate for Vayne)
