Karthus Mid Lane is ranked S Tier and has a 62.37% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 93 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Sorcerer's Shoes, Liandry's Anguish, Archangel's Staff, Zhonya's Hourglass, Rabadon's Deathcap, and Shadowflame. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Tear of the Goddess, Health Potion, and Stealth Ward. Karthus's Best Spellbook Mid Lane matchups include Katarina, Veigar, and Zed. Karthus's Best Spellbook Mid Lane counters are Ekko, Lux, and Vel'Koz.
Karthus Summoner Spells





Karthus Starting Items








Karthus Runes
Karthus Items








Karthus Skill Order
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Karthus Item Purchase Order























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Karthus Trinkets



Karthus Boots



Karthus Mythic Items




