Karthus Mid Lane is ranked S Tier and has a 62.37% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 93 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Sorcerer's Shoes, Liandry's Anguish, Archangel's Staff, Zhonya's Hourglass, Rabadon's Deathcap, and Shadowflame. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Tear of the Goddess, Health Potion, and Stealth Ward. Karthus's Best Spellbook Mid Lane matchups include Katarina, Veigar, and Zed. Karthus's Best Spellbook Mid Lane counters are Ekko, Lux, and Vel'Koz.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Item Purchase Order
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3000Karthus Ultimate Spellbook Stats
Karthus Trinkets
Karthus Boots
Karthus Mythic Items
Best Jungle Duo Queue Champions for Karthus Mid Lane in Ultimate Spellbook(over 51% win rate with Karthus)
Average Jungle Duo Queue Champions for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate with Karthus)
Even Mid Lane Matchups for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate for Karthus)
