Tier: AWin60.71%Role17.13%Pick0.51%Games: 56KDA: 2.54Score: 53.16
Karthus Mid Lane is ranked A Tier and has a 60.71% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 56 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Liandry's Anguish, Sorcerer's Shoes, Archangel's Staff, Rabadon's Deathcap, Shadowflame, and Void Staff. For runes, the strongest choice is Inspiration (Primary) with First Strike (Keystone), and Domination (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Tear of the Goddess, Health Potion, and Stealth Ward. Karthus's Best Spellbook Mid Lane matchups include Akshan and Zed.
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Karthus Summoner Spells


Win %
Pick %
61%
100%
59%
96%

100%
4%
Karthus Starting Items
Win %
Buy %



2

47%
27%



2

56%
16%
Karthus Runes
Win %
Pick %
69%
34%
81%
10%
37%
20%
83%
7%
Karthus Items

65%

60%

61%

71%

81%

58%

55%

94%
Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
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![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Item Purchase Order






















Karthus Ultimate Spellbook Stats

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Karthus Trinkets
Win %
Buy %

55%
91%

50%
21%

67%
11%
Karthus Boots
Win %
Buy %

60%
95%

50%
11%
Karthus Mythic Items
Win %
Buy %

65%
86%

58%
21%