Vayne Mid Lane is ranked B Tier and has a 47.99% win rate in LoL Ultimate Spellbook Patch 14.20. We've analyzed 181 Vayne Mid Lane games to compile our statistical Vayne Spellbook Build Guide. For items, our build recommends: Berserker's Greaves, Blade of The Ruined King, Guinsoo's Rageblade, Wit's End, Kraken Slayer, and Terminus. For runes, the strongest choice is Precision (Primary) with Lethal Tempo (Keystone), and Resolve (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Doran's Blade, Long Sword, Health Potion, and Stealth Ward. Vayne's Best Spellbook Mid Lane matchups include Aurelion Sol, Caitlyn, and Fizz. Vayne's Best Spellbook Mid Lane counters are Sylas, Ekko, and Lux.
Vayne Summoner Spells
Vayne Starting Items
Vayne Runes
Vayne Items
Vayne Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Vayne Item Purchase Order
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Vayne Trinkets
Vayne Boots
Vayne Situational Items
Average Jungle Duo Queue Champions for Vayne Mid Lane in Ultimate Spellbook(49% - 51% win rate with Vayne)
Even Mid Lane Matchups for Vayne Mid Lane in Ultimate Spellbook(49% - 51% win rate for Vayne)
