Karthus Mid Lane is ranked B Tier and has a 57.50% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 333 Karthus Mid Lane games to compile our statistical Karthus Spellbook Build Guide. For items, our build recommends: Liandry's Anguish, Sorcerer's Shoes, Archangel's Staff, Shadowflame, Demonic Embrace, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Tear of the Goddess, Boots, Health Potion, and Stealth Ward. Karthus's Best Spellbook Mid Lane matchups include Corki, Twisted Fate, and Xerath. Karthus's Best Spellbook Mid Lane counters are Annie, Ekko, and Heimerdinger.
Karthus Summoner Spells
Karthus Starting Items
Karthus Runes
Karthus Items
Karthus Skill Order
 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
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 | Q | Q | Q | Q | Q | |||||||||||||
 | W | W | W | W | W | |||||||||||||
 | E | E | E | E | E | |||||||||||||
 | R | R | R |
Karthus Item Purchase Order
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30003600Karthus Ultimate Spellbook Stats
Karthus Trinkets
Karthus Boots
Karthus Mythic Items
Average Jungle Duo Queue Champions for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate with Karthus)
Even Mid Lane Matchups for Karthus Mid Lane in Ultimate Spellbook(49% - 51% win rate for Karthus)
