Tier: BWin52.08%Role12.03%Pick0.14%Ban0.31%Games: 97KDA: 2.15Score: 52.05
Karthus Mid Lane is ranked B Tier and has a 52.08% win rate in LoL Patch 25.10. We've analyzed 97 Karthus Mid Lane games to compile our statistical Karthus Build Guide. For items, our build recommends: Malignance, Sorcerer's Shoes, Blackfire Torch, Archangel's Staff, Liandry's Torment, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Sorcery (Secondary). The optimal Summoner Spells for this build are Ignite and Exhaust. Starting items should include Tear of the Goddess, Health Potion, and Stealth Ward. Karthus's Best Mid Lane matchups include Veigar, Xerath, and Yasuo. Karthus's Best Mid Lane counters are Malzahar and Viktor.
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Karthus Summoner Spells


Win %
Pick %
53%
59%
57%
53%

51%
42%

50%
37%

20%
5%

50%
2%
Karthus Starting Items
Win %
Buy %


2

54%
61%


2

47%
33%
Karthus Runes
Win %
Pick %
54%
62%
38%
19%
67%
6%
50%
4%
Karthus Items

53%

58%

48%

56%

46%

66%

51%

67%
Karthus Skill Order
![]() | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | Q | Q | Q | Q | Q | |||||||||||||
![]() | W | W | W | W | W | |||||||||||||
![]() | E | E | E | E | E | |||||||||||||
![]() | R | R | R |
Karthus Item Purchase Order

























Karthus Trinkets
Win %
Buy %

51%
96%

67%
12%

70%
10%
Karthus Boots
Win %
Buy %

58%
54%

33%
6%

100%
1%

0%
1%
Karthus Situational Items
Win %
Buy %

62%
22%

60%
21%

64%
14%

57%
14%

64%
11%

80%
5%