Karthus Lane is ranked B Tier and has a 48.38% win rate in LoL Nexus Blitz Patch 13.23. We've analyzed 2811 Karthus Lane games to compile our statistical Karthus Nexus Blitz Build Guide. For items, our build recommends: Liandry's Anguish, Sorcerer's Shoes, Archangel's Staff, Shadowflame, Rabadon's Deathcap, and Void Staff. For runes, the strongest choice is Domination (Primary) with Dark Harvest (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Flash and Ignite. Starting items should include Doran's Ring, Health Potion, and Stealth Ward. Karthus's Best Nexus Blitz Lane matchups include Blitzcrank, Briar, and Evelynn. Karthus's Best Nexus Blitz Lane counters are Urgot, Sejuani, and Warwick.