Seraphine Lane is ranked S+ Tier and has a 60.94% win rate in LoL Nexus Blitz Patch 13.23. We've analyzed 22920 Seraphine Lane games to compile our statistical Seraphine Nexus Blitz Build Guide. For items, our build recommends: Liandry's Anguish, Sorcerer's Shoes, Rylai's Crystal Scepter, Archangel's Staff, Cosmic Drive, and Rabadon's Deathcap. For runes, the strongest choice is Sorcery (Primary) with Arcane Comet (Keystone), and Inspiration (Secondary). The optimal Summoner Spells for this build are Flash and Ignite. Starting items should include Doran's Ring, Health Potion, and Stealth Ward. Seraphine's Best Nexus Blitz Lane matchups include Udyr, Rek'Sai, and Lulu. Seraphine's Best Nexus Blitz Lane counters are Amumu, Alistar, and Leona.