Caitlyn ADC is ranked S+ Tier and has a 49.71% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 140663 Caitlyn ADC games to compile our statistical Caitlyn Spellbook Build Guide. For items, our build recommends: Berserker's Greaves, Galeforce, The Collector, Rapid Firecannon, Infinity Edge, and Lord Dominik's Regards. For runes, the strongest choice is Precision (Primary) with Lethal Tempo (Keystone), and Domination (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Pickaxe, Health Potion, and Stealth Ward. Caitlyn's Best Spellbook ADC matchups include Taliyah, Senna, and Azir. Caitlyn's Best Spellbook ADC counters are Karthus, Xerath, and Miss Fortune.