Vayne ADC is ranked S+ Tier and has a 54.00% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 70128 Vayne ADC games to compile our statistical Vayne Spellbook Build Guide. For items, our build recommends: Berserker's Greaves, Immortal Shieldbow, Phantom Dancer, Blade of The Ruined King, Wit's End, and Bloodthirster. For runes, the strongest choice is Precision (Primary) with Lethal Tempo (Keystone), and Domination (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Vampiric Scepter, Health Potion, and Stealth Ward. Vayne's Best Spellbook ADC matchups include Quinn, Varus, and Vladimir. Vayne's Best Spellbook ADC counters are Taliyah, Karthus, and Heimerdinger.