Cassiopeia Mid Lane is ranked B Tier and has a 43.92% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 8000 Cassiopeia Mid Lane games to compile our statistical Cassiopeia Spellbook Build Guide. For items, our build recommends: Liandry's Anguish, Archangel's Staff, Zhonya's Hourglass, Cosmic Drive, Rylai's Crystal Scepter, and Morellonomicon. For runes, the strongest choice is Precision (Primary) with Conqueror (Keystone), and Domination (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Tear of the Goddess, Health Potion, and Stealth Ward. Cassiopeia's Best Spellbook Mid Lane matchups include Varus, Riven, and Zoe. Cassiopeia's Best Spellbook Mid Lane counters are Aatrox, Kennen, and Pyke.