Lissandra Mid Lane is ranked A Tier and has a 56.85% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 12679 Lissandra Mid Lane games to compile our statistical Lissandra Spellbook Build Guide. For items, our build recommends: Luden's Tempest, Sorcerer's Shoes, Zhonya's Hourglass, Horizon Focus, Morellonomicon, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Electrocute (Keystone), and Sorcery (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Doran's Ring, Health Potion, and Stealth Ward. Lissandra's Best Spellbook Mid Lane matchups include Aurelion Sol, Ezreal, and Gwen. Lissandra's Best Spellbook Mid Lane counters are Kayle, Karthus, and Kassadin.