Syndra Mid Lane is ranked A Tier and has a 53.14% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 15619 Syndra Mid Lane games to compile our statistical Syndra Spellbook Build Guide. For items, our build recommends: Luden's Tempest, Sorcerer's Shoes, Shadowflame, Zhonya's Hourglass, Rabadon's Deathcap, and Void Staff. For runes, the strongest choice is Domination (Primary) with Electrocute (Keystone), and Sorcery (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Amplifying Tome, Doran's Ring, Health Potion, and Stealth Ward. Syndra's Best Spellbook Mid Lane matchups include Renekton, Nunu, and Seraphine. Syndra's Best Spellbook Mid Lane counters are Kayle, Xerath, and Pyke.