Kai'Sa Mid Lane is ranked Off Meta Tier and has a 42.07% win rate in LoL Ultimate Spellbook Patch 11.24. We've analyzed 6733 Kai'Sa Mid Lane games to compile our statistical Kai'Sa Spellbook Build Guide. For items, our build recommends: Berserker's Greaves, Manamune, Luden's Tempest, Nashor's Tooth, The Collector, and Rabadon's Deathcap. For runes, the strongest choice is Domination (Primary) with Hail of Blades (Keystone), and Precision (Secondary). The optimal Summoner Spells for this build are Placeholder and Flash. Starting items should include Doran's Blade, Tear of the Goddess, Health Potion, and Stealth Ward. Kai'Sa's Best Spellbook Mid Lane matchups include Galio, Aurelion Sol, and Zilean. Kai'Sa's Best Spellbook Mid Lane counters are Cassiopeia, Karthus, and Pantheon.